Organometallic Glutathione S-Transferase Inhibitors
نویسندگان
چکیده
منابع مشابه
Isolation of glutathione-S-transferase inhibitors.
doxorubicin8). Inhibitors of this enzyme, ethacrynic acid and piriprost are already known and their potential therapeutic utility in combination with alkylating agents has been suggested by Tew and his colleagues9). Our group has been screening for novel inhibitors of glutathione S-transferase from microbial origin and we recently isolated tryptophandehydrobutyrine diketopiperazine10) (TDD) and...
متن کاملStudies of endogenous inhibitors of microsomal glutathione S-transferase.
Glutathione S-transferase is present in rat liver microsomal fraction, but its activity is low relative to the transferase activity present in the soluble fraction of the hepatocyte. We have found, however, that the activity of microsomal glutathione S-transferase is increased 5-fold after treatment with small unilamellar vesicles made from phosphatidylcholine. The increase in activity is due t...
متن کاملTwo glutathione S-transferase inhibitors from Radix Angelicae sinensis.
Chemotherapy for malignant tumors fails because of multidrug resistance (MDR). The overexpression of glutathione S-transferase (GST) with MDR is considered one of the major obstacles to successful cancer chemotherapy. High-throughput screening was performed to search for inhibitors of GST from natural products. Two compounds isolated from Radix Angelicae sinensis had an inhibitory effect on GST...
متن کاملProapoptotic activity of new glutathione S-transferase inhibitors.
Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) P1-1, an enzyme which displays antiapoptotic activity and is also involved in the cellular resistance to anticancer drugs. These new inhibitors are not tripeptide glutathione-peptidomimetic molecules and display lipophylic properties suitable for crossing the p...
متن کاملEstrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents.
BACKGROUND Dysmenorrhea is the most common gynecologic complaint among adolescent females. We investigated the association between genetic polymorphisms and dysmenorrhea. METHODS A total of 202 postmenarcheal Korean female adolescents 16-17 yr old participated in this study. Genotyping for glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), glutathione S-transfe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organometallics
سال: 2017
ISSN: 0276-7333,1520-6041
DOI: 10.1021/acs.organomet.7b00468